McDonnell Creek State School follows the Australian National Curriculum, delivering the following subjects:
English
Mathematics
Science
Humanities and Social Sciences (HASS)
The Arts (Visual Arts, Media Arts, Music, Dance, Drama)
Technologies
Health and Physical Education (HPE)
Instrumental Music (Years 4-6)
- LOTE- Japanese delivered through Cairns School of Distance Education, for Year 5 and 6 only
Religious instruction is not currently offered.